HALO® BIOCLASS蛋白质色谱柱包括1000 Å Fused-Core®填料，均容许大分子能够不受限制地进入孔隙，从而为生物药的研发赋予了超快速以及高分辨的分析能力。
随着复杂生物制药的不断发展，经常需要对药物分子进行结构修饰，而这些修饰会在蛋白质链、糖基化位点和自由巯基等方面发生细微差别，从而产生变异体。
HALO® BIOCLASS 蛋白分析柱之特色：
- 相对于较小的孔径和非核壳型的填料， 具有完全的孔表面可达性，从而使半峰宽更窄，回收率更高
- 能够应用于UHPLC、HPLC和LC-MS等仪器
- 优异的高温稳定性（最高可达90˚C），峰形和回收率均比同类产品要好
- 在低温条件下可实现高回收率的、不同的键合相
Applications
- mAbs
- ADCs
- Biosimilars
- H/D exchange
- Fragments
Features
- Outstanding temperature stability up to 90 °C
- Compatible with UHPLC, HPLC and MS
- Elution of very large proteins with excellent peak shape and recovery
- Very low LCMS bleed
Available Particles
TOTAL PORE ACCESS FOR HIGH RESOLUTION
The large pores of the HALO® 1000 Å C4 column allow improved access to the stationary phase and increased resolution for IgG2 isoforms compared to the smaller 300 Å pores of the FPP C4 column.
FAST AND EFFICIENT RESOLUTION
Very high resolution is obtained between variants of light and heavy chains of a reduced and alkylated monoclonal antibody (IgG1) sample using a HALO® 400 Å Protein C4 column.
Featured Documents
Application Notes
Technical Literature
Catalog
Guidebook
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